Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants.

doi:10.1128/JVI.72.5.3520-3523.1998

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Article

Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants.

Journal of virology - 1 May 1998

Yerly S, Rakik A, De Loes S K, Hirschel B, Descamps D, Brun-Vézinet F, Perrin L

Abstract excerpt

Sequences of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) domain were determined by direct sequencing of HIV-1 RNA in successive plasma samples from eight seroconverting patients infected with virus bearing the T215Y/F amino acid substitution associated with zidovudi...

Topics

Amino Acids
Anti-HIV Agents
Cells, Cultured
Codon
Drug Resistance, Microbial
Genes, Viral
Genetic Heterogeneity
Genetic Variation
HIV Reverse Transcriptase
HIV Seropositivity
HIV-1
Humans
Microbial Sensitivity Tests
Mutagenesis, Site-Directed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reverse Transcriptase Inhibitors

Sequence Analysis, DNA

Zidovudine

Source

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Identifiers

PMID: 9557630
DOI: 10.1128/JVI.72.5.3520-3523.1998
PMCID: PMC109570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9557630-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.