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Article

Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease.

Ophthalmology - 1 Jan 2007

Tedeschi-Blok Nicole, Buckley Jonathan, Varma Rohit, Triche Timothy J, Hinton David R

Abstract excerpt

OBJECTIVE: Recently, a strong association has been observed for the complement factor H (CFH) Tyr402His polymorphism with early and advanced age-related macular degeneration (AMD) in independent non-Hispanic White, clinic-based, case-control studies. These studies suggest the CFH His402 allele is a major risk allele in early and advanced AMD, explaining 43% to 70% of all AMD in older adults. We utilized a...

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Source

Identifiers

PMID: 17198853
DOI: 10.1016/j.ophtha.2006.07.043

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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