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Article

Association of complement factor H Y402H gene polymorphism with different subtypes of exudative age-related macular degeneration.

Ophthalmology - 1 Apr 2007

Wegscheider Beate J, Weger Martin, Renner Wilfried, Steinbrugger Iris, März Winfried, Mossböck Georg, Temmel Werner, El-Shabrawi Yosuf, Schmut Otto, Jahrbacher Renate, Haas Anton

Abstract excerpt

OBJECTIVE: Exudative age-related macular degeneration (AMD) is a common cause for a severe central visual loss. The complement system has been implicated in the pathogenesis of drusen. Recently, a complement factor H (CFH) polymorphism, which is characterized by a tyrosine (Y)-to-histidine (H) exchange at position 402 of the CFH gene, has been suggested as a major risk factor for AMD in a North American...

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Source

Identifiers

PMID: 17398321
DOI: 10.1016/j.ophtha.2006.07.048

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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