Article
Analysis of the Y402H variant of the complement factor H gene in age-related macular degeneration.
Investigative ophthalmology & visual science - 1 Oct 2006
Baird Paul N, Islam F M Amirul, Richardson Andrea J, Cain Melinda, Hunt Nicola, Guymer Robyn
Abstract excerpt
PURPOSE: Recent studies in U.S. populations have indicated that the Y402H variant of the complement factor H (CFH) gene contains a major risk susceptibility allele for age-related macular degeneration (AMD). This study was conducted to ascertain whether this is also true in a non-U.S. population and also whether the at-risk allele is associated with the clinical phenotype of disease and the age at diagnosis....
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