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Article

The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.

European journal of cell biology - 1 Dec 2007

Burnworth Bettina, Arendt Susanne, Muffler Sonja, Steinkraus Volker, Bröcker Eva B, Birek Catalina, Hartschuh Wolfgang, Jauch Anna, Boukamp Petra

Abstract excerpt

As proposed by Hanahan and Weinberg (2000. Cell 100, 57-70) carcinogenesis requires crucial events such as (i) genomic instability, (ii) cell cycle deregulation, (iii) induction of a telomere length maintenance mechanism, and (iv) an angiogenic switch. By comparing the expression of p53, cyclin D1, p16, hTERT, and TSP-1 in spontaneously regressing keratoacanthoma (KA) as a paradigm of early neoplasia, with...

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PMID: 17198740
DOI: 10.1016/j.ejcb.2006.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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