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Article

Sunburn and p53 in the onset of skin cancer.

Nature - 1 Jan 2000

Ziegler A, Jonason A S, Leffell D J, Simon J A, Sharma H W, Kimmelman J, Remington L, Jacks T, Brash D E

Abstract excerpt

Squamous cell carcinoma of the skin (SCC) can progress by stages: sun-damaged epidermis, with individual disordered keratinocytes; actinic keratosis (AK), spontaneously regressing keratinized patches having aberrant cell differentiation and proliferation; carcinoma in situ; SCC and metastasis. To understand how sunlight acts as a carcinogen, we determined the stage at which sunlight mutates the p53...

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Source

Identifiers

PMID: 7997263
DOI: 10.1038/372773a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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