Sunburn and p53 in the onset of skin cancer.

doi:10.1038/372773a0

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Article

Sunburn and p53 in the onset of skin cancer.

Nature - 1 Jan 2000

Ziegler A, Jonason A S, Leffell D J, Simon J A, Sharma H W, Kimmelman J, Remington L, Jacks T, Brash D E

Abstract excerpt

Squamous cell carcinoma of the skin (SCC) can progress by stages: sun-damaged epidermis, with individual disordered keratinocytes; actinic keratosis (AK), spontaneously regressing keratinized patches having aberrant cell differentiation and proliferation; carcinoma in situ; SCC and metastasis. To...

Topics

Animals
Apoptosis
Carcinoma, Squamous Cell
DNA Mutational Analysis
Genes, p53
Humans
Keratosis
Mice
Mice, Inbred C57BL
Mutation
Neoplasms, Radiation-Induced
Skin
Skin Neoplasms
Sunburn
Sunlight
Ultraviolet Rays

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