Article
The role of Gc protein oligosaccharide structure as a risk factor for COPD.
Anticancer research - 1 Jan 2000
Ohkura Kazuto, Nagasawa Hideko, Uto Yoshihiro, Okamura Natsuko, Murakami Aya, Hori Hitoshi
Abstract excerpt
BACKGROUND: The risk of chronic obstructive pulmonary disease (COPD) is related to Gc protein allele type, such as Gc*1F, Gc*IS, Gc*2. It has been reported that Gc*1F increased COPD risk, while Gc*2 suppressed the risk. Thus, the allele type of Gc protein is an important factor in COPD. These Gc proteins differ in sugar composition at Thr418 or Thr420. In this study, features of the sugar structure of modeled Gc...
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