Differential glycosylation in mutant vitamin D-binding protein decimates the binding stability of vitamin D.

Abstract excerpt

Vitamin D (VD) is produced by the skin upon exposure to sunlight or is obtained from dietary sources. Several risk factors are associated with VD deficiency including mutations and post-translational modifications in its transport protein known as vitamin D binding protein (VDBP) or GC-globulin. The two common single nucleotide polymorphisms rs7041 and rs4588 create three major isoforms of VDBP, including GC-1F...

Topics

Join the communities discussing this publication.

• Glycosylation
• Molecular Dynamics Simulation
• Mutant Proteins