Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigation of the impact of nonsynonymous mutations on thyroid peroxidase dimer.

PloS one - 1 Jan 2023

Begum Mst Noorjahan, Mahtarin Rumana, Ahmed Sinthyia, Shahriar Imrul, Hossain Shekh Rezwan, Mia Md Waseque, Qadri Syed Saleheen, Qadri Firdausi, Mannoor Kaiissar, Akhteruzzaman Sharif

Abstract excerpt

Congenital hypothyroidism is one of the most common preventable endocrine disorders associated with thyroid dysgenesis or dyshormonogenesis. Thyroid peroxidase (TPO) gene defect is mainly responsible for dyshormonogenesis; a defect in the thyroid hormone biosynthesis pathway. In Bangladesh, there is limited data regarding the genetic etiology of Congenital Hypothyroidism (CH). The present study investigates the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Hypothyroidism
Share to Hydrogen Peroxide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iodide Peroxidase

Share to Ligands

Share to Molecular Docking Simulation

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 37699049
DOI: 10.1371/journal.pone.0291386
PMCID: PMC10497151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of the impact of nonsynonymous mutations on thyroid peroxidase dimer.PMID 37699049Read ↗

A Computational Approach: The Functional Effects of Thyroid Peroxidase Variants in Thyroid Cancer and Genetic Disorders.Semantic proximity Read ↗

Molecular Investigation of TSHR gene in Bangladeshi Congenital Hypothyroid patientsSemantic proximity Read ↗

Molecular investigation of TSHR gene in Bangladeshi congenital hypothyroid patients.Semantic proximity Read ↗

SNP mutations occurring in thyroid hormone receptor influenced individual susceptibility to triiodothyronine: Molecular dynamics and site-directed mutagenesis approaches.Semantic proximity Read ↗

Genetics and phenomics of hypothyroidism and goiter due to TPO mutations.Semantic proximity Read ↗

Screening and Functional Analysis of TPO Gene Mutations in a Cohort of Chinese Patients With Congenital Hypothyroidism.Semantic proximity Read ↗

Thyroid Peroxidase Gene Mutations Associated with Thyroid Disorders.Semantic proximity Read ↗

High-Resolution Melt Curve Analysis: An Approach for Mutation Detection in the TPO Gene of Congenital Hypothyroid Patients in BangladeshSemantic proximity Read ↗

Central dogma in thyroid dysfunction: a review on structure modification of TSHR as a cornerstone for thyroid abnormalities.Semantic proximity Read ↗

Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.Semantic proximity Read ↗

Structural and catalytic consequences of active-site vs. distal mutations in human dehalogenase: insights from molecular dynamics simulations.Semantic proximity Read ↗

Curating the gnomAD database: Report of novel variants in the thyroid peroxidase gene using in silico bioinformatics algorithms and a literature review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.