Article

Structural mechanism of MUC5AC mucin net-like polymer formation and its SNP variability that affect risk of the lung diseases COPD and IPF

2024-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Gel-forming mucins MUC5AC and MUC5B constitute the main structural component of the mucus in the respiratory system. Secreted mucins interact specifically with each other and other molecules giving mucus specific properties. We determined the cryoEM structures of the wild type MUC5AC-D3 assembly and the structural SNP variants R996Q and R1201W. Our structures explain the basis of MUC5AC N-termin...

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Literature Corpus work: 463c370c-cd2a-5dba-aa29-f47a1ed46a82
DOI: 10.1101/2024.08.02.606332

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