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Article

SCGB1A1 rs3741240 variant downregulates CC16: a molecular insight into COPD pathogenesis in Indian population.

Frontiers in immunology - 1 Jan 2025

Sultana Nasima, Adhikari Himani, Goswami Achintya Mohan, Mondal Amalesh, Ganai Indranil, Biswas Himani, Iqbal Asif, Das Aratrika, Moitra Saibal, Podder Sanjoy

Abstract excerpt

Background: Chronic Obstructive Pulmonary Disease (COPD) is a progressive inflammatory lung disorder influenced by environmental and genetic factors. The rs3741240 polymorphism in the SCGB1A1 gene, which encodes the anti-inflammatory protein CC16, is considered a genetic marker of COPD susceptibility. Objective: This study aimed to investigate the functional significance of the SCGB1A1 rs3741240 polymorphism in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41459543
DOI: 10.3389/fimmu.2025.1689340
PMCID: PMC12740939

Genes

SCGB1A1
AGO2
HAND1
HAND2
SMAD1
TF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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