Article
Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2007
Kirn-Safran Catherine B, Oristian Daniel S, Focht Richard J, Parker Shaila G, Vivian Jay L, Carson Daniel D
Abstract excerpt
Because of their deleterious effects on developing organisms, ribosomal protein (RP) mutations have been poorly described in mammals, and only a few heterozygous mutations have been shown to be viable. This observation is believed to be due to the fact that each RP is an essential component in the assembly of a functional stable ribosome. Here, we created gene targeted mutant mice lacking HIP/RPL29, an RP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.