Article
Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning.
Cell - 29 Apr 2011
Kondrashov Nadya, Pusic Aya, Stumpf Craig R, Shimizu Kunihiko, Hsieh Andrew C, Ishijima Junko, Shiroishi Toshihiko, Barna Maria
Abstract excerpt
Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprising tissue-specific patterning defects, including pronounced homeotic transformations of the axial skeleton. In Rpl38 mutant embryos, global protein synthesis is unchanged; however the...
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