Article
Synthesis and function of ribosomal proteins--fading models and new perspectives.
The FEBS journal - 1 Jun 2009
Caldarola Sara, De Stefano Maria Chiara, Amaldi Francesco, Loreni Fabrizio
Abstract excerpt
The synthesis of ribosomal proteins (RPs) has long been known to be a process strongly linked to the growth status of the cell. In vertebrates, this coordination is dependent on RP mRNA translational efficiency, which changes according to physiological circumstances. Despite many years of investigation, the trans-acting factors and the signaling pathways involved in this regulation are still elusive. At the same...
Topics
- Animals
- Disease Models, Animal
- Humans
- Models, Biological
- Mutation
- Protein Biosynthesis
- Protein Transport
- Ribosomal Proteins
- Signal Transduction