Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence analysis of the proximal promoter region of the human alpha-fetoprotein gene in hepatocellular carcinoma.

Cancer letters - 30 Jan 1994

Igarashi K, Aoyagi Y, Ohkoshi S, Yokota T, Mori S, Suda T, Kamimura T, Asakura H

Abstract excerpt

We have examined whether or not mutations exist in the proximal promoter region of the human alpha-fetoprotein (AFP) gene in the hepatocellular carcinoma (HCC) tissue. Genomic DNA was extracted from four patients: one HCC tissue, one HCC and its corresponding non-cancerous (cirrhosis) tissues, one liver cirrhosis (LC) tissue without HCC and one matching HCC tissue and peripheral blood leukocytes. Serum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA, Neoplasm
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to Promoter Regions, Genetic

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 7511984
DOI: 10.1016/0304-3835(94)90383-2

Genes

AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence analysis of the proximal promoter region of the human alpha-fetoprotein gene in hepatocellular carcinoma.PMID 7511984Read ↗

Single nucleotide polymorphism in the promoter region of human alpha-fetoprotein (AFP) gene and its significance in hepatocellular carcinoma (HCC).Semantic proximity Read ↗

cis-Acting Elements and Transcription Factors Involved in the Promoter Activity of the Human Factor VIII GeneSemantic proximity Read ↗

Alpha-fetoprotein gene polymorphisms and risk of HCC and cirrhosis.Semantic proximity Read ↗

Hereditary persistence of alpha-fetoprotein is due to both proximal and distal hepatocyte nuclear factor-1 site mutations.Semantic proximity Read ↗

Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients.Semantic proximity Read ↗

A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma.Semantic proximity Read ↗

Functional Characterization of the Human Factor VII 5′-Flanking RegionSemantic proximity Read ↗

A novel hepatocytic transcription factor that binds the alpha-fetoprotein promoter-linked coupling element.Semantic proximity Read ↗

A new mutation in the HNF4 binding region of the factor VII promoter in a patient with severe factor VII deficiency.Semantic proximity Read ↗

The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3 (FOXA).Semantic proximity Read ↗

Two common functional polymorphisms in the promoter region of the coagulation factor VII gene determining plasma factor VII activity and mass concentration.Semantic proximity Read ↗

A G-->A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.