Article
Sequence analysis of the proximal promoter region of the human alpha-fetoprotein gene in hepatocellular carcinoma.
Cancer letters - 30 Jan 1994
Igarashi K, Aoyagi Y, Ohkoshi S, Yokota T, Mori S, Suda T, Kamimura T, Asakura H
Abstract excerpt
We have examined whether or not mutations exist in the proximal promoter region of the human alpha-fetoprotein (AFP) gene in the hepatocellular carcinoma (HCC) tissue. Genomic DNA was extracted from four patients: one HCC tissue, one HCC and its corresponding non-cancerous (cirrhosis) tissues, on...
Topics
- Adult
- Base Sequence
- Carcinoma, Hepatocellular
- DNA, Neoplasm
- Female
- Gene Amplification
- Humans
- Leukocytes
- Liver Cirrhosis
- Liver Neoplasms
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Sequence Analysis, DNA
- alpha-Fetoproteins