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Article

Single nucleotide polymorphism in the promoter region of human alpha-fetoprotein (AFP) gene and its significance in hepatocellular carcinoma (HCC).

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Sept 2007

Chen G G, Ho R L K, Wong J, Lee K F, Lai P B S

Abstract excerpt

BACKGROUND: Variations of serum AFP levels in HCC patients and cell lines are likely due to the differential activity of enhancer/silencer elements that control AFP. To understand the potential mechanism underlying the differential expression of AFP, we have examined the sequence of the AFP promoter in HCC. METHODS: Direct DNA sequencing was carried out to sequence 980 bp of AFP promoter of DNA samples isolated...

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Share to alpha-Fetoproteins
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to DNA, Neoplasm

Share to Immunoenzyme Techniques

Share to Liver Neoplasms

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Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 17433605
DOI: 10.1016/j.ejso.2007.02.036

Genes

AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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