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Article

Hereditary persistence of alpha-fetoprotein is due to both proximal and distal hepatocyte nuclear factor-1 site mutations.

Gastroenterology - 1 Jan 2004

Alj Youssef, Georgiakaki Maria, Savouret Jean-François, Mal Frédéric, Attali Pierre, Pelletier Gilles, Fourré Catherine, Milgrom Edwin, Buffet Catherine, Guiochon-Mantel Anne, Perlemuter Gabriel

Abstract excerpt

BACKGROUND AND AIMS: The molecular mechanism of hereditary persistence of alpha-fetoprotein (HPAFP) has been previously described in a large Scottish family, consisting of a -119G>A substitution in the distal hepatocyte nuclear factor 1 (HNF-1) binding site of the alpha-fetoprotein (AFP) gene promoter. We report here the molecular mechanisms of HPAFP in 2 new unrelated families. METHODS: Family 1 was of Bengali...

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Share to alpha-Fetoproteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Hepatocyte Nuclear Factor 1

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Hepatocyte Nuclear Factor 1-beta

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Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 14699509
DOI: 10.1053/j.gastro.2003.10.073

Genes

AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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