Article
The impact of epidermal growth factor receptor gene status on gefitinib-treated Japanese patients with non-small-cell lung cancer.
International journal of cancer - 15 Mar 2007
Ichihara Shuji, Toyooka Shinichi, Fujiwara Yoshiro, Hotta Katsuyuki, Shigematsu Hisayuki, Tokumo Masaki, Soh Junichi, Asano Hiroaki, Ichimura Kouichi, Aoe Keisuke, Aoe Motoi, Kiura Katsuyuki, Shimizu Kenji, Date Hiroshi, Shimizu Nobuyoshi
Abstract excerpt
We investigated the relationships between genetic factors and clinical outcome in Japanese non-small-cell lung cancer (NSCLC) patients treated with gefitinib. Ninety-eight NSCLC patients who had been treated with gefitinib, were screened for mutations in epidermal growth factor receptor (EGFR) ex...
Topics
- Aged
- Antineoplastic Agents
- Carcinoma, Non-Small-Cell Lung
- Dinucleotide Repeats
- Drug Resistance, Neoplasm
- ErbB Receptors
- Female
- Gefitinib
- Humans
- Lung Neoplasms
- Male
- Mutation
- Polymorphism, Genetic