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Article

Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer.

Journal of cancer research and clinical oncology - 1 May 2008

Sasaki Hidefumi, Endo Katsuhiko, Okuda Katsuhiro, Kawano Osamu, Kitahara Naoto, Tanaka Hisaichi, Matsumura Akihide, Iuchi Keiji, Takada Minoru, Kawahara Masaaki, Kawaguchi Tomoya, Yukiue Haruhiro, Yokoyama Tomoki, Yano Motoki, Fujii Yoshitaka

Abstract excerpt

To evaluate the epidermal growth factor receptor (EGFR) protein expression, gene mutations and amplification as predictors of clinical outcome in patients with non-small-cell lung cancer (NSCLC) receiving gefitinib, we have performed fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). We investigated the EGFR amplification and EGFR protein expression statuses in 27 surgically treated...

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PMID: 17932690
DOI: 10.1007/s00432-007-0320-z

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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