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Article

Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small-cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2006

Kimura Hideharu, Kasahara Kazuo, Kawaishi Makoto, Kunitoh Hideo, Tamura Tomohide, Holloway Brian, Nishio Kazuto

Abstract excerpt

Cases of non-small-cell lung cancer (NSCLC) carrying the somatic mutation of epidermal growth factor receptor (EGFR) have been shown to be hyperresponsive to the EGFR tyrosine kinase inhibitor gefitinib (IRESSA). If EGFR mutations can be observed in serum DNA, this could serve as a noninvasive source of information on the genotype of the original tumor cells that could influence treatment and the ability to...

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PMID: 16818687
DOI: 10.1158/1078-0432.CCR-05-2324

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small-cell lung cancer.PMID 16818687Read ↗

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