Article
EGFR polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI.
Yonsei medical journal - 1 Nov 2012
Jung Minkyu, Cho Byoung Chul, Lee Chul Ho, Park Hyung Soon, Kang Young Ae, Kim Se Kyu, Chang Joon, Kim Dae Jun, Rha Sun Young, Kim Joo Hang, Lee Ji Hyun
Abstract excerpt
PURPOSE: Mutations in the epidermal growth factor receptor (EGFR) have been confirmed as predictors of the efficacy of treatment with EGFR-tyrosine kinase inhibitors (TKIs). We investigated whether polymorphisms of the EGFR gene were associated with clinical outcomes in non-small cell lung cancer (NSCLC) patients treated with EGFR-TKI. MATERIALS AND METHODS: A polymorphic dinucleotide repeat in intron 1 [CA...
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