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Article

EGFR mRNA is upregulated, but somatic mutations of the gene are hardly found in renal cell carcinoma in Japanese patients.

Pharmaceutical research - 1 Oct 2005

Sakaeda Toshiyuki, Okamura Noboru, Gotoh Akinobu, Shirakawa Toshiro, Terao Shuji, Morioka Masahi, Tokui Kenji, Tanaka Hisato, Nakamura Tsutomu, Yagi Mariko, Nishimura Yoshihiro, Yokoyama Mitsuhiro, Okumura Katsuhiko

Abstract excerpt

PURPOSE: Heterozygous somatic mutations of epidermal growth factor receptor (EGFR) in exons 18, 19, and 21 were recently reported to be associated with response to gefitinib in patients having nonsmall cell lung cancer. Such mutations are more frequently found among Japanese than Europeans. In this work, the frequency of mutations was investigated in renal cell carcinoma (RCC) samples obtained from Japanese...

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Source

Identifiers

PMID: 16180134
DOI: 10.1007/s11095-005-7094-2

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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