Article
Comparative analysis of epidermal growth factor receptor mutations and gene amplification as predictors of gefitinib efficacy in Japanese patients with nonsmall cell lung cancer.
Cancer - 1 May 2007
Sone Takashi, Kasahara Kazuo, Kimura Hideharu, Nishio Kazuto, Mizuguchi Masayuki, Nakatsumi Yasuto, Shibata Kazuhiko, Waseda Yuko, Fujimura Masaki, Nakao Shinji
Abstract excerpt
BACKGROUND: Because the investigation of epidermal growth factor receptor gene (EGFR) status as a predictor of gefitinib efficacy in Japanese patients has shown promise, the authors evaluated EGFR mutations and gene amplification in biopsy specimens from Japanese patients with nonsmall cell lung cancer (NSCLC) who received treatment with gefitinib to analyze the correlation between EGFR gene status and clinical...
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