Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the conserved DRY motif on G protein activation of rat angiotensin II receptor type 1A.

Biochemical and biophysical research communications - 29 Mar 2002

Ohyama Kenji, Yamano Yoshiaki, Sano Tomoaki, Nakagomi Yoshiko, Wada Manabu, Inagami Tadashi

Abstract excerpt

To delineate the functional importance of the highly conserved triplet amino acid sequence, Asp-Arg-Tyr (DRY) among G protein-coupled receptors in the second intracellular loop, these residues of rat angiotensin II (Ang II) receptor type 1A (AT(1A)) were changed by alanine or glycine by site-directed mutagenesis. These mutant receptors were stably expressed in CHO-K1 cells, and the binding of Ang II, GTP effect,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Angiotensin II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CHO Cells

Share to Guanosine 5'-O-(3-Thiotriphosphate)

Share to Heterotrimeric GTP-Binding Proteins

Share to Inositol 1,4,5-Trisphosphate

Share to Receptor, Angiotensin, Type 1

Share to Receptors, Angiotensin

Source

Identifiers

PMID: 11906170
DOI: 10.1006/bbrc.2002.6670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the conserved DRY motif on G protein activation of rat angiotensin II receptor type 1A.PMID 11906170Read ↗

Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors.Semantic proximity Read ↗

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.Semantic proximity Read ↗

Mutations of the conserved DRS motif in the second intracellular loop of the gonadotropin-releasing hormone receptor affect expression, activation, and internalization.Semantic proximity Read ↗

Mutations of the DRY motif that preserve beta 2-adrenoceptor coupling.Semantic proximity Read ↗

Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors.Semantic proximity Read ↗

Angiotensin II type 1 receptor-function affected by mutations in cytoplasmic loop CD.Semantic proximity Read ↗

Relationship between ligand binding and YIPP motif in the C-terminal region of human AT1 receptor.Semantic proximity Read ↗

Characterization of functional roles of DRY motif in the 2nd intracellular loop of dopamine D2 and D3 receptors.Semantic proximity Read ↗

Aliphatic amino acids in helix VI of the AT(1) receptor play a relevant role in agonist binding and activity.Semantic proximity Read ↗

Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors.Semantic proximity Read ↗

AT1 receptor blocker-insensitive mutant AT1A angiotensin receptors reveal the presence of G protein-independent signaling in C9 cells.Semantic proximity Read ↗

Single mutations at Asn295 and Leu305 in the cytoplasmic half of transmembrane alpha-helix domain 7 of the AT1 receptor induce promiscuous agonist specificity for angiotensin II fragments: a pseudo-constitutive activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.