Article
Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors.
Biochemical and biophysical research communications - 17 May 2002
Chung Duane A, Wade Susan M, Fowler Carol B, Woods Danielle D, Abada Paolo B, Mosberg Henry I, Neubig Richard R
Abstract excerpt
In G protein-coupled receptors (GPCRs), a conserved aspartic acid in the DRY motif at the cytoplasmic end of helix 3 regulates the transition to the active state, while the adjacent arginine is crucial for G protein activation. To examine the functions of these two residues, we made D130I and R131Q mutations in the alpha2A adrenergic receptor (AR). We demonstrate that, unlike other GPCRs, the alpha2A AR is not...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.