Article
Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study.
Diabetes - 1 Jan 2007
North Kari E, Franceschini Nora, Borecki Ingrid B, Gu C Charles, Heiss Gerardo, Province Michael A, Arnett Donna K, Lewis Cora E, Miller Michael B, Myers Richard H, Hunt Steven C, Freedman Barry I
Abstract excerpt
Recent studies have demonstrated the importance of sex effects on the underlying genetic architecture of insulin-related traits. To explore sex-specific genetic effects on fasting insulin, we tested for genotype-by-sex interaction and conducted linkage analysis of fasting insulin in Hypertension Genetic Epidemiology Network families. Hypertensive siblings and their first-degree relatives were recruited from five...
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