Article
Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Feb 2007
McCarthy Jeanette J
Abstract excerpt
BACKGROUND: Despite decades of research, the genetic basis of coronary heart disease and its metabolic risk factors is poorly understood. Few studies consider that sex may modify the effect of gene variants on disease. Investigation of gene by sex interaction may help to elucidate underlying genetic susceptibilities and explain the sexual dimorphism of these complex traits. AIMS: The aim of this review is to...
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