Article
A genome-wide association study identifies genetic determinants of hemoglobin glycation index with implications across sex and ethnicity.
Frontiers in endocrinology - 1 Jan 2024
House John S, Breeyear Joseph H, Akhtari Farida S, Evans Violet, Buse John B, Hempe James, Doria Alessandro, Mychaleckyi Josyf C, Fonseca Vivian, Shi Mengyao, Li Changwei, Liu Shuqian, Kelly Tanika N, Rotroff Daniel, Motsinger-Reif Alison A
Abstract excerpt
Introduction: We investigated the genetic determinants of variation in the hemoglobin glycation index (HGI), an emerging biomarker for the risk of diabetes complications. Methods: We conducted a genome-wide association study (GWAS) for HGI in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (N = 7,913) using linear regression and additive genotype encoding on variants with minor allele...
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