Article
Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity.
Hepatology (Baltimore, Md.) - 1 Jul 1998
Toivola D M, Omary M B, Ku N O, Peltola O, Baribault H, Eriksson J E
Abstract excerpt
The function and regulation of keratin 8 (K8) and 18 (K18), intermediate filament (IF) proteins of the liver, are not fully understood. We employed the liver damage induced by microcystin-LR (MC-LR), a liver-specific inhibitor of type-1 and type-2A protein phosphatases, in normal and in keratin a...
Topics
- Animals
- Enzyme Inhibitors
- Female
- Humans
- Intermediate Filament Proteins
- Keratins
- Liver
- Male
- Marine Toxins
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Microcystins
- Mutation
- Peptides, Cyclic