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Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory‐Denk body formation

23 Feb 2012

Abstract excerpt

Mallory-Denk bodies (MDBs) are hepatocyte inclusions that are associated with poor liver disease prognosis. The intermediate filament protein keratin 8 (K8) and its cross-linking by transglutaminase-2 (TG2) are essential for MDB formation. K8 hyperphosphorylation occurs in association with liver injury and MDB formation, but the link between keratin phosphorylation and MDB formation is unknown. We used a...

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PMID: 22362895
DOI: 10.1096/fj.11-198580

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