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Article

The APOBEC-2 crystal structure and functional implications for the deaminase AID.

Nature - 25 Jan 2007

Prochnow Courtney, Bransteitter Ronda, Klein Michael G, Goodman Myron F, Chen Xiaojiang S

Abstract excerpt

APOBEC-2 (APO2) belongs to the family of apolipoprotein B messenger RNA-editing enzyme catalytic (APOBEC) polypeptides, which deaminates mRNA and single-stranded DNA. Different APOBEC members use the same deamination activity to achieve diverse human biological functions. Deamination by an APOBEC protein called activation-induced cytidine deaminase (AID) is critical for generating high-affinity antibodies, and...

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Identifiers

PMID: 17187054
DOI: 10.1038/nature05492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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