Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease.

doi:10.1371/journal.pone.0012037

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Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease.

PloS one - 6 Aug 2010

Santoro Aurelia, Balbi Valentina, Balducci Elisa, Pirazzini Chiara, Rosini Francesca, Tavano Francesca, Achilli Alessandro, Siviero Paola, Minicuci Nadia, Bellavista Elena, Mishto Michele, Salvioli Stefano, Marchegiani Francesca, Cardelli Maurizio, Olivieri Fabiola, Nacmias Benedetta, Chiamenti Andrea Maria, Benussi Luisa, Ghidoni Roberta, Rose Giuseppina, Gabelli Carlo, Binetti Giuliano, Sorbi Sandro, Crepaldi Gaetano, Passarino Giuseppe, Torroni Antonio, Franceschi Claudio

Abstract excerpt

BACKGROUND: Alzheimer's Disease (AD) is the most common neurodegenerative disease and the leading cause of dementia among senile subjects. It has been proposed that AD can be caused by defects in mitochondrial oxidative phosphorylation. Given the fundamental contribution of the mitochondrial genome (mtDNA) for the respiratory chain, there have been a number of studies investigating the association between mtDNA...

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PMID: 20700462
DOI: 10.1371/journal.pone.0012037
PMCID: PMC2917370

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