Article
Several mutations in the melanocortin 4 receptor gene are associated with obesity in Chinese children and adolescents.
Journal of endocrinological investigation - 1 Nov 2006
Wang C L, Liang L, Wang H J, Fu J F, Hebebrand J, Hinney A
Abstract excerpt
AIM: To screen mutations in the melanocortin 4 receptor (MC4R) in obese and normal-weight Chinese children and adolescents. METHODS: Three hundred Chinese children and adolescents, including 200 obese and 100 healthy non-obese individuals, were evaluated. The coding region of the MC4R gene was amplified by polymerase chain reaction (PCR) and sequenced. RESULTS: In obese individuals, we detected two novel...
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