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Article

Familial early-onset obesity in Turkish children: variants and polymorphisms in the melanocortin-4 receptor (MC4R) gene.

Journal of pediatric endocrinology & metabolism : JPEM - 25 May 2022

Kırmızıbekmez Heves, Kendir Demirkol Yasemin, Akgün Doğan Özlem, Seymen Gülcan, İnan Balcı Elif, Atla Pınar, Dursun Fatma

Abstract excerpt

OBJECTIVES: Genetic factors have a key role in childhood obesity with higher rates in children than adults. Among the monogenic types of non-syndromic obesity, melanocortin-4 receptor (MC4R) deficiency is the most frequent cause. Beside pathogenic variants, single-nucleotide polymorphisms in MC4R gene are also associated with lower energy expenditure. The aim of this study was to estimate the frequency of MC4R...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptor, Melanocortin, Type 4

Source

Identifiers

PMID: 35355494
DOI: 10.1515/jpem-2021-0756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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