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Article

A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity.

Diabetes - 1 Jan 2002

Kobayashi Hiromasa, Ogawa Yoshihiro, Shintani Mitsuyo, Ebihara Ken, Shimodahira Makiko, Iwakura Toshio, Hino Megumu, Ishihara Takashi, Ikekubo Katsuji, Kurahachi Hiroyuki, Nakao Kazuwa

Abstract excerpt

The melanocortin-4 receptor (MC4R) is a member of the seven membrane-spanning G protein-coupled receptor superfamily and signals through the activation of adenylyl cyclase. The MC4R mutations are the most common known monogenic cause of human obesity. However, no such mutations have been found in...

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Identifiers

PMID: 11756348
DOI: 10.2337/diabetes.51.1.243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11756348-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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