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Article

Identification and characterization of two novel melanocortin-3 receptor mutations in Chinese obese individuals.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2021

Wang Wei, Lin Yue-Jun, Chen Zhao-Xia, Guo Dong-Yu

Abstract excerpt

The melanocortin-3 receptor (MC3R) and melanocortin-4 receptor (MC4R), known as neural melanocortin receptors, have been implicated to be critical components of the hypothalamic leptin-melanocortin pathway and related to obesity pathogenesis. In contrast to extensive evidence from physiologic, biological, genetic studies demonstrating that MC4R is a critical regulator in obesity, whether MC3R mutation causes...

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Identifiers

PMID: 33621651
DOI: 10.1016/j.bbadis.2021.166107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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