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Article

Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis.

Progress in molecular biology and translational science - 1 Jan 2013

Hinney Anke, Volckmar Anna-Lena, Knoll Nadja

Abstract excerpt

The melanocortin-4 receptor gene (MC4R) has intensively been analyzed in molecular genetic obesity research. Decreased MC4R activity leads to obesity. Currently 166 nonsynonymous, nonsense, deletion, and frameshift MC4R mutations have been described. Vast numbers of these mutations were identified in (extremely) obese individuals. Total or partial loss of MC4R function results from most detected mutations, as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

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Identifiers

PMID: 23317785
DOI: 10.1016/B978-0-12-386933-3.00005-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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