Article
Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia.
Human molecular genetics - 1 Feb 2007
Sundar Purnima Desai, Yu Chang-En, Sieh Weiva, Steinbart Ellen, Garruto Ralph M, Oyanagi Kiyomitsu, Craig Ulla-Katrina, Bird Thomas D, Wijsman Ellen M, Galasko Douglas R, Schellenberg Gerard D
Abstract excerpt
Unusual forms of amyotrophic lateral sclerosis (ALS-G), Parkinsonism dementia complex (PDC-G) and Guam dementia (GD) are found in Chamorros, the indigenous people of Guam. Neurofibrillary tangles composed of hyperphosphorylated tau are a neuropathologic feature of these closely related disorders. To determine if variation in the gene that encodes microtubule-associated protein tau gene (MAPT) contributes to risk...
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