Article
Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates.
Human molecular genetics - 1 Oct 2009
Sieh Weiva, Choi Yoonha, Chapman Nicola H, Craig Ulla-Katrina, Steinbart Ellen J, Rothstein Joseph H, Oyanagi Kiyomitsu, Garruto Ralph M, Bird Thomas D, Galasko Douglas R, Schellenberg Gerard D, Wijsman Ellen M
Abstract excerpt
Amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a fatal neurodegenerative disease found in the Chamorro people of Guam and other Pacific Island populations. The etiology is unknown, although both genetic and environmental factors appear important. To identify loci for ALS/PDC, we conducted both genome-wide linkage and association analyses, using approximately 400 microsatellite markers,...
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