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Genome-Wide Analysis of the Parkinsonism-Dementia Complex of Guam

1 Dec 2004

Abstract excerpt

BACKGROUND: Parkinsonism-dementia complex (PDC) is a neurofibrillary tangle degeneration involving the deposition of Alzheimer-type tau, predominantly in the mesial temporal cortex, brainstem, and basal ganglia. It occurs in focal geographic isolates, including Guam and the Kii peninsula of Japan. The familial clustering of the disease has suggested that a genetic factor could be important in its etiology....

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PMID: 15596609
DOI: 10.1001/archneur.61.12.1889

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