Article
TAU as a susceptibility gene for amyotropic lateral sclerosis-parkinsonism dementia complex of Guam.
Archives of neurology - 1 Nov 2001
Poorkaj P, Tsuang D, Wijsman E, Steinbart E, Garruto R M, Craig U K, Chapman N H, Anderson L, Bird T D, Plato C C, Perl D P, Weiderholt W, Galasko D, Schellenberg G D
Abstract excerpt
BACKGROUND: A Guam variant of amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia complex (PDC-G) are found in the Chamorro people of Guam. Both disorders have overlapping neuropathologic findings, with neurofibrillary tangles in spinal cord and brain. The cause of ALS-G-PDC-G is unknown, although inheritance and environment appear important. Because neurofibrillary tangles containing tau protein are...
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