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Article

ApoE and CYP2D6 polymorphism with and without parkinsonism-dementia complex in the people of Chamorro, guam.

Neurology - 1 Sept 1996

Chen X, Xia Y, Gresham L S, Molgaard C A, Thomas R G, Galasko D, Wiederholt W C, Saitoh T

Abstract excerpt

Parkinsonism-dementia complex (PDC), a neurodegenerative disorder in the Chamorro, Guam population, has been epidemiologically ascribed to the ingestion of the neurotoxin cycasin. This disease is characterized neuropathologically by the presence of abundant neurofibrillary tangles (NFTs). We analyzed a genetic risk factor of Alzheimer's disease (AD), apolipoprotein E, hypothesized to be linked to NFT formation,...

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Source

Identifiers

PMID: 8797479
DOI: 10.1212/wnl.47.3.779

Genes

PDC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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