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Article

Defining neurodegeneration on G uam by targeted genomic sequencing

5 Jan 2015

Abstract excerpt

OBJECTIVE: Amyotrophic lateral sclerosis/parkinsonism-dementia complex has been described in Guam, Western Papua, and the Kii Peninsula of Japan. The etiology and pathogenesis of this complex neurodegenerative disease remains enigmatic. METHODS: In this study, we have used targeted genomic sequencing to evaluate the contribution of genetic variability in the pathogenesis of amyotrophic lateral sclerosis,...

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PMID: 25558820
DOI: 10.1002/ana.24346

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