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Article

Glucocorticoid receptor variant and risk of dementia and white matter lesions.

Neurobiology of aging - 1 May 2008

van Rossum Elisabeth F C, de Jong Frank Jan, Koper Jan W, Uitterlinden André G, Prins Niels D, van Dijk Ewoud J, Koudstaal Peter J, Hofman Albert, de Jong Frank H, Lamberts Steven W J, Breteler Monique M B

Abstract excerpt

OBJECTIVE: Elevated glucocorticoid levels are associated with dementia. A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities. METHODS: This study was performed in two prospective population-based cohort studies among elderly. The first study included 6034...

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PMID: 17184882
DOI: 10.1016/j.neurobiolaging.2006.11.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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