Article

Cre/LoxP-HBV plasmids generating recombinant covalently closed circular DNA genome upon transfection

2020-07-21

Abstract excerpt

New therapies against hepatitis B virus (HBV) require the elimination of covalently closed circular DNA (cccDNA), the episomal HBV genome. HBV plasmids containing an overlength 1.3-mer genome and bacterial backbone (pHBV1.3) are used in many different models, but do not replicate the unique features of cccDNA. Since the stable cccDNA pool is a barrier to HBV eradication in patients, we developed a recombinant circ...

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Literature Corpus work: 2fb58d9d-2c91-5b18-a28a-43f182e19dea
DOI: 10.1101/2020.07.21.214171

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