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Article

Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2007

Chaudhuri Saumya R, Mallam Joshua N, Chévez-Barrios Patricia, Wadhwa Lalita, Ng Philip, Hurwitz Mary Y, Hurwitz Richard L

Abstract excerpt

Adenovirus infection is a significant cause of ocular, respiratory, and gastrointestinal illness and can spread rapidly. Morbidity is considerable in immune-suppressed individuals and there is significant mortality. There are no effective therapies. During preclinical studies of adenoviral-mediated gene therapy for ocular disorders, we noticed a significant increase in transduction when the target cells were...

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Share to Adenoviridae
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to Hyaluronan Receptors

Share to Hyaluronic Acid

Share to Mice, Inbred C57BL

Share to Transduction, Genetic

Source

Identifiers

PMID: 17180120
DOI: 10.1038/sj.mt.6300044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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