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Article

Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction.

Human gene therapy - 1 Oct 2012

Messina Emily L, Nienaber Jeffrey, Daneshmand Mani, Villamizar Nestor, Samulski Jude, Milano Carmelo, Bowles Dawn E

Abstract excerpt

Adeno-associated virus type 3b (AAV3b) has been largely ignored by gene therapists because of the inability of vectors based on this serotype to transduce target tissues efficiently. Here we describe a phenomenon unique to AAV3b in that vectors based on this serotype mediate enhanced transduction in the presence of heparin. Among the many biological functions attributed to heparin, its interaction with, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptor, Fibroblast Growth Factor, Type 2

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Source

Open in PubMed Open full text

Identifiers

PMID: 22680698
DOI: 10.1089/hum.2012.066
PMCID: PMC3472518

Genes

FGFR2
FGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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