Article
The transduction of Coxsackie and Adenovirus Receptor-negative cells and protection against neutralizing antibodies by HPMA-co-oligolysine copolymer-coated adenovirus.
Biomaterials - 1 Dec 2011
Wang Chung-Huei K, Chan Leslie W, Johnson Russell N, Chu David S H, Shi Julie, Schellinger Joan G, Lieber André, Pun Suzie H
Abstract excerpt
Adenoviral (AdV) gene vectors offer efficient nucleic acid transfer into both dividing and non-dividing cells. However issues such as vector immunogenicity, toxicity and restricted transduction to receptor-expressing cells have prevented broad clinical translation of these constructs. To address this issue, engineered AdV have been prepared by both genetic and chemical manipulation. In this work, a polymer-coated...
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