Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression.

The Journal of biological chemistry - 21 Sept 2012

Ildefonso Cristhian J, Bond Wesley S, Al-Tawashi Azza R, Hurwitz Mary Y, Hurwitz Richard L

Abstract excerpt

The success of gene therapy in the ocular environment is partly due to the presence of hyaluronan in vitreous. Here we explore the mechanism of hyaluronan-mediated enhancement of adenoviral vector transgene expression. Introduction of hyaluronan receptor CD44 into CD44-negative cells followed by transduction in the presence of vitreous with an adenoviral vector containing an IL-12-coding transgene increases IL-12...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Amyloid Precursor Protein Secretases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to Hyaluronan Receptors

Share to Hyaluronic Acid

Share to Interleukin-12

Share to Proteolysis

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 22865879
DOI: 10.1074/jbc.M112.347369
PMCID: PMC3463356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression.PMID 22865879Read ↗

Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44.Semantic proximity Read ↗

Intra‐articular gene delivery and expression of interleukin‐1Ra mediated by self‐complementary adeno‐associated virusSemantic proximity Read ↗

Activation of the Cellular Unfolded Protein Response by Recombinant Adeno-Associated Virus VectorsSemantic proximity Read ↗

<i>Ex Vivo</i> Serotype-Specific Transduction of Equine Joint Tissue by Self-Complementary Adeno-Associated Viral VectorsSemantic proximity Read ↗

Adeno‐associated virus gene transfer in Morquio A disease – effect of promoters and sulfatase‐modifying factor 1Semantic proximity Read ↗

Integration of adeno-associated virus 2 DNA in human MKR melanoma cells induces a peptide with oncosuppressive properties.Semantic proximity Read ↗

IL-17 sequestration via salivary gland gene therapy in a mouse model of Sjogren’s syndrome suppresses disease-associated expression of the putative autoantigen Klk1b22Semantic proximity Read ↗

Restricted expression of an adenoviral vector encoding Fas ligand (CD95L) enhances safety for cancer gene therapy.Semantic proximity Read ↗

Adeno-Associated Vector mediated gene transfer of Transforming Growth Factor -beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolismSemantic proximity Read ↗

Lentiviral Vector Design for Optimal T Cell Receptor Gene Expression in the Transduction of Peripheral Blood Lymphocytes and Tumor-Infiltrating LymphocytesSemantic proximity Read ↗

Expression of human collagenase I (MMP-1) and TIMP-1 in a baculovirus-based expression system.Semantic proximity Read ↗

Disease- and cell-type-specific transcriptional targeting of vectors for osteoarthritis gene therapy: further development of a clinical canine model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.