Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells.

The Journal of biological chemistry - 14 Nov 2003

Zoltan-Jones Alexandra, Huang Lei, Ghatak Shibnath, Toole Bryan P

Abstract excerpt

During carcinoma progression, tumor cells often undergo changes similar (but not identical) to epithelialmesenchymal transitions in embryonic development. In this study, we demonstrate that experimental stimulation of hyaluronan synthesis in normal epithelial cells is sufficient to induce mesenchymal and transformed characteristics. Using recombinant adenoviral expression of hyaluronan synthase-2, we show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Drug Combinations
Share to Gelatinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucuronosyltransferase

Share to Hyaluronic Acid

Share to Keratins

Share to Laminin

Share to Proteoglycans

Source

Identifiers

PMID: 12954618
DOI: 10.1074/jbc.M308168200

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells.PMID 12954618Read ↗

TGFβ and matrix-regulated epithelial to mesenchymal transitionSemantic proximity Read ↗

Myofibroblastic differentiation leads to hyaluronan accumulation through reduced hyaluronan turnover.Semantic proximity Read ↗

Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration.Semantic proximity Read ↗

The regulatory effect of hyaluronan on human mesenchymal stem cells’ fate modulates their interaction with cancer cells in vitroSemantic proximity Read ↗

Hyaluronan-Cell Interactions in Cancer and Vascular DiseaseSemantic proximity Read ↗

Human neoplastic submandibular intercalated duct cells express an acinar phenotype when cultured on a basement membrane matrix.Semantic proximity Read ↗

Cytokines and growth factors stimulate hyaluronan production: role of hyaluronan in epithelial to mesenchymal-like transition in non-small cell lung cancer.Semantic proximity Read ↗

Requirement of multiple signaling pathways for the augmented production of hyaluronan by v-Src.Semantic proximity Read ↗

Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone.Semantic proximity Read ↗

Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44.Semantic proximity Read ↗

Multiple aspects of the phenotype of mammary epithelial cells transformed by expression of activated M-Ras depend on an autocrine mechanism mediated by hepatocyte growth factor/scatter factor.Semantic proximity Read ↗

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.